Author  
Place of duty  
Title   성인 급성 백혈병에서 MDR 1 mRNA 유전자의 발현 ( Multidrug Resistance ( MDR 1 ) Gene Expression in Adult Acute Leukemia : Espression of P-glycoprotein and MDR 1 mRNA and its implication on clinical outcome in adult )
Publicationinfo   1995 Jan; 027(06): 1017-1030.
Key_word   Acute leukemia, MDR 1 mRNA, P-glycoprotein
Full-Text  
Abstract   Resistance to multiple chemotherapeutic agents is mainly related to the production of P- glycoproteins, a transmembrane drug efflux pump that is encoded by the multidrug resistance(MDR) gene, MDR I. To investigate whether MDR 1 could be involved in clinical resistance to chemotherapy in adult acute leukemias, We have analyzed prospectively 39 samples from 32 patients(27 at presentation, 5 after relapse) with acute leukemia for the evaluation of overexpression of MDR 1 mRNA and P-glycoprotein by using polymerase chain reactions(PCR) and flow cytometric assay, respectively. The induction rate of first complete remission differed between MDR 1 mRNA-positive and negative groups(37% v 84%, respectively; p=0.02). The survival rate(Kaplan-Meier method) in MDR 1 mRNA negative group was significantly higher than that in MDR 1 mRNA positive group(p=0.02). These results suggest that PCR assay of MDR 1 mRNA is a convenient method to detect expression of MDR 1 gene, and it may be a prognostic factor in the treatment of acute leukemia.
저 자   김형준(Hyeoung Joon Kim),정익주(Ik Joo Chung),서재성(Jae Sung Seo),최경상(Keyong Sang Choi),박무림(Moo Rim Park),백광우(Kang Woo Baek),배열(Youl Bae)